Electrical communication in lymphangions

Contractions of lymphangions, i.e. the segment between two one-way lymphatic valves, generate the pressure gradients that propel lymph back to the circulation. Each lymphangion is comprised of an inner sheet of lymphatic endothelial cells (LECs) circumscribed by one or more layers of lymphatic muscle cells (LMCs). Each contraction is produced by LMC action potentials (APs) that propagate via gap junctions along the lymphangion. Yet, electrical coupling within and between cell layers and the impact on AP-waves is poorly understood.

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