First clinical isolation of an azole-resistant Aspergillus fumigatus harboring a TR46/Y121F/T289A mutation in South America. [PublishAheadOfPrint]

One of the most recently described Aspergillus fumigatus CYP51A-mediated azole resistance mechanism is the named TR46/Y121F/T289A. Clinical A. fumigatus strains harboring these substitutions were reported worldwide with the exception of South-America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (one year later than the firstly described mutant in US) demonstrating that these alleles were scattered worldwide before than previously thought.

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