Genetic and Biochemical Characterization of OXA-535, a distantly-related OXA-48-like {beta}-lactamase. [PublishAheadOfPrint]

OXA-535, a chromosome-encoded OXA-48-like carbapenemase of Shewanella bicestrii JAB-1, shared only 91.3% of amino-acid sequence identity, but displayed similar catalytic efficiencies as compared to OXA-48, except for ertapenem. OXA-535 and OXA-436, a plasmid-encoded variant of OXA-535 differing by three amino acids, form a novel cluster of distantly-related OXA-48-like carbapenemases. Comparison of bla_OXA-535 and bla_OXA-436 genetic environments suggests that an ISCR1 may be responsible of bla_OXA-436 gene mobilization from the chromosome of Shewanella spp. to plasmids.

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