Small sharp spikes as EEG markers of mesiotemporal lobe epilepsy

Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy (Asadi-Pooya et al., 2016; Stern and Engel Jr., 2015). It classically presents with focal seizures with aura, automatisms, impaired awareness, and sometimes progression to generalized convulsive seizures. However, the diagnostic evaluation of patients with mTLE can be prolonged and imperfect because pathological hippocampal activity cannot consistently be identified on scalp EEG (Koessler et al., 2015; Ramantani et al., 2016).

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