Pharmacodynamic target attainment for cefepime, meropenem and piperacillin/tazobactam using a pharmacokinetic/pharmacodynamic-based dosing calculator in critically ill patients [PublishAheadOfPrint]

This was a prospective study to determine if pharmacokinetic/pharmacodynamic (PK/PD)-based antibiotic dosing software aids in achieving concentration targets in critically ill patients receiving cefepime (n=10), meropenem (n=20), or piperacillin/tazobactam (n=19). Antibiotic calculator doses targeting >90% probability of target attainment (PTA) differed from package-insert doses for 22.4% (11/49) patients. Target attainment was achieved for 98% of patients (48/49). A PK/PD based antibiotic dosing calculator provides beta-lactam doses with high likelihood of PTA in critically ill patients.

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