Radiation-induced lung density changes on CT scan for NSCLC: no impact of dose-escalation level or volume

Understanding the regional dose volume effects of lung parenchyma damage induction is crucial to dissect the causes of the multifactorial radiation-induced pulmonary toxicity. The relationship between dose and lung density changes on CT 3 months after treatment was therefore analyzed in the prospective dataset of a dose-escalation study in NSCLC. Lung Hounsfield Unit increase saturated above 60 Gy EQD2 and was independent of dose-escalation level and volume. Mild responses were observed peripherally in the lung.

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