GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency

Extensive epigenetic reprogramming occurs during the transition from naive ESCs to formative EpiLCs. Blelloch and colleagues show that the transcription factor GRHL2 rewires a subset of enhancers during the transition without altering cognate gene expression. By doing so, GRHL2 subdivides the naive pluripotency network prior to lineage diversification.

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