A dose prediction model for duodenum sparing with a biodegradable hydrogel spacer for pancreatic cancer radiotherapy

We established an OVH prediction model to guide the selection of pancreatic cancer patients who may benefit from hydrogel spacer injection before radiation for duodenum sparing. We evaluated the model's accuracy by verifying predictions of the required hydrogel spacer thickness to achieve clinical dose constraints. Our upcoming clinical trials can utilize this technique to ensure sufficient separation between the duodenum and pancreas for consideration of dose-escalated radiation therapy.

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