TFE3 is a diagnostic marker for solid pseudopapillary neoplasms of the pancreas

Aberrant Wnt signaling is a hallmark of solid pseudopapillary neoplasms of the pancreas (SPN). Transcription factor E3 (TFE3) plays a critical role in activation and regulation of the Wnt pathway, and is predicted to be a candidate gene implicated in SPN by gene regulatory network analysis. The aim of this study was to evaluate TFE3 as a marker for SPN. Paraffin embedded tissues of SPN (n = 75) and other primary pancreatic tumors were analyzed, including pancreatic neuroendocrine tumors (PanNET) (n = 17), pancreatic ductal adenocarcinomas (PDAC) (n = 14), pancreatic neuroendocrine carcinomas (PanNEC) (n = 4) and acinar cell carcinomas (ACC) (n = 3).

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