SASH1, a potential therapeutic target for cancer

We read with interest the paper by Zhou et al. [1], reporting that downregulated SASH1 expression indicated poor clinical prognosis in gastric cancer. Xie et al. [2] also found that downregulation of SASH1 correlated with poor prognosis in cervical cancer. Chen et al. [3] investigated the effects of the SASH1 gene in A549 human lung cancer cells and found that SASH1 may inhibit A549 cell growth and proliferation. Similarly, the overexpression of SASH1 may also be related to the decreased migration of A549 human lung cancer cells.

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