hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate

Ozair et al. show that major classes of cortical DPNs can be specified from subplate neurons (SPNs) derived from hPSCs by modulating post-mitotic WNT signaling. The findings indicate that SPNs have evolved in primates as an important contributor to cortical lamination. These findings have implications for understanding neurodevelopmental disorders.

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