Issue Highlights

Barrett's esophagus is a known risk factor for esophageal adenocarcinoma. Current clinical practice guidelines recommend endoscopic surveillance for Barrett's esophagus patients to allow early detection of dysplasia or carcinoma, but endoscopic surveillance of Barrett's esophagus is inefficient. Risk stratification of patients might improve the effectiveness of surveillance. In this issue of Clinical Gastroenterology and Hepatology, Krishnamoorthi and colleagues1 reported results of a systematic review and meta-analysis of 20 cohort studies including approximately 75,000 patients and found increasing age, male gender, smoking, increasing Barrett's esophagus segment length, and low-grade dysplasia were associated with increase in risk of progression of Barrett's esophagus to high-grade dysplasia or esophageal adenocarcinoma.

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