Virtual bronchoscopy-guided treatment planning to map and mitigate radiation-induced airway injury in lung SAbR

Radiation injury to airways during lung stereotactic ablative radiotherapy can lead to reduced respiratory function post-radiotherapy. In this work, we use virtual bronchoscopy to map the airway tree and develop a risk-based model of the radiosensitivity of individual airway segments. Using this model, we develop a treatment planning strategy that mitigates the risk of airway collapse while meeting the prescribed clinical dosimetric goals for the tumor target and organs at risk.

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