(P28) Challenges in the Re-Irradiation of Locally Advanced Head and Neck Cancers: Outcomes and Toxicity from a Single Institution

Managing locoregional recurrence after radiation therapy (RT) remains a challenge in head and neck (HN) cancer. Many of these recurrences present at advanced stages and are unable to be completely resected. Re-irradiation (re-RT) is a potentially curative treatment for previously irradiated, unresectable, head and neck cancers. Re-irradiation carries increased risk of severe and potentially life threatening radiation related toxicities. We reviewed our institutional experience using intensity modulated radiation therapy (IMRT) to re-irradiate patients with advanced HN recurrences to identify predictors of outcomes and toxicity.

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