(OA11) Timing of Radiotherapy for Pediatric Patients With Parameningeal Rhabdomyosarcoma With Intracranial Extension

This study was designed to assess clinical outcomes and patterns of failure, particularly as regards the timing of radiotherapy (RT), for pediatric patients with parameningeal rhabdomyosarcoma with intracranial extension (ICE-PM-RMS). Patients with ICE-PM-RMS have high rates of local and central nervous system (CNS) relapse, and historically have been treated with RT at week 0 of chemotherapy to improve disease-related outcomes. The recently-completed Children's Oncology Group (COG) ARST0531 trial delayed RT for these patients to week 4, and the ongoing COG protocol ARST1431 is further deferring RT until week 13 of chemotherapy.

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