PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification

Cohen et al. show that Polycomb repressive complex 1 (PRC1), a critical chromatin regulator, is essential for skin epithelium morphogenesis and stem cell specification. By coupling in vivo chromatin and transcriptional profiling with loss-of-function studies, the authors show that PRC1 controls skin development through regulation of silent and active genes.

https://ift.tt/2rhe7Vi