WEE1 Kinase Inhibition Reverses DNA Damage Checkpoint Activation to Sensitize Oral Cancer Cells to Immunotherapy

Most head and neck cancers harbor genomically altered TP53, resulting in dependence on G2/M DNA damage checkpoint activation for cell cycle control. Here, we describe G2/M DNA damage checkpoint activation as a tumor cell intrinsic mechanism of resistance to cytotoxic T-lymphocyte (CTL) killing.

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