Prognostic Factors Associated With Progression-Free Survival in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Treated With Induction Chemotherapy Followed By Chemoradiation Therapy

Chemoradiation therapy (CRT) is the standard of care for locally advanced head and neck squamous cell carcinoma (LAHNSCC). Induction chemotherapy (IC) with TPF (taxane, CDDP, FU) has shown benefit compared to PF (CDDP, FU), but its use is controversial. Response to IC may be associated with further response to CRT. We hypothesized that response to IC is an independent prognostic factor associated with PFS. Objective: to analyze the PFS of patients with LAHNSCC (larynx[L], hypopharynx[HP], oropharynx[OP], oral cavity[OC]), treated with IC followed by CRT, according to response to IC and CRT.

http://ift.tt/2Ip8hcc