Treatment Intensification for HPV-Unrelated Head and Neck Squamous Cell Carcinoma With Nab-Paclitaxel-Based Chemotherapy followed by Cisplatin and Radiation Therapy

In human papillomavirus (HPV)-unrelated head and neck squamous cell carcinoma (HNSCC), locoregional relapse (LRR) is the most common cause of treatment failure. Following cisplatin and radiation therapy (CisRT), the LRR rate at two years is 25%-35% (RTOG 0129, 0522, 91-11). We present our experience of treatment intensification for HPV-unrelated HNSCC with nab-paclitaxel-based chemotherapy followed by CisRT.

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