Corneal Thickness Response after Anesthetic Eye Drops: Our Own Results and Meta-Analysis

We aimed to test if there are different patterns in the central corneal thickness (CCT) response after instilling oxybuprocaine anesthetic eye drops and also to determine whether there is a significant change in the CCT. CCT was measured in 60 eyes of 60 healthy subjects before and during the hour after oxybuprocaine 0.4% eye drops were instilled. In addition, a systematic review and meta-analysis were carried out in order to answer the following PICO (patient, intervention, comparison, and outcome) question: What effect do anesthetic eye drops have on CCT values? We found no significant changes in the mean CCT values during the hour's observation (ANOVA, ), and the meta-analysis revealed no statistically significant changes in the CCT after anesthesia (-Value = 1.111; value = 1.000; = 0.000; Tau2 = 0.000; Stderr = 0.020). However, we found three CCT response patterns 5 minutes after anesthesia: Pattern 1, subjects with no significant changes in their CCT values (, 46.7%); Pattern 2, subjects with significant CCT increases (, 36.7%); and Pattern 3, subjects with significant CCT decreases (, 16.7%). In sum, there are no significant changes in the CCT after anesthesia, but there are three different CCT response patterns 5 minutes after anesthesia.

http://ift.tt/2Fftqnc