Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae [PublishAheadOfPrint]

The occurrence of heavy metal resistance genes in multi-resistant Enterobacteriaceae possessing bla_NDM-1 or bla_CTX-M-15 genes were examined by PCR and S1-PFGE. When compared with clinical susceptible isolates (10.0-30.0%), the pcoA, merA, silC and arsA genes occurred with higher frequencies in bla_NDM-1 (48.8-71.8%) and bla_CTX-M-15 (19.4-52.8%) positive isolates, and they are mostly located on plasmids. Given the high association of metal resistance genes with multidrug resistant Enterobacteriaceae, the use of heavy metals in hospitals and the environment needs increased vigilance.

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