Update: Topical Anesthetics for Pain Control During Repair of Dermal Laceration

The authors included 25 randomized controlled trials with a total of 3,278 adult and pediatric patients. They found that various topical cocaine-free agents provided adequate analgesia; however, comparison of specific agents was not possible because of high risk of bias among comparison studies. In 2 pooled studies, self-reported improvement in visual analog scale scores (0 to 100 mm), the improvement was greater for topical prilocaine-phenylephrine compared with topical tetracaine-epinephrine-cocaine, with a difference of 5.6 points.

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