Coming to Terms with Cardiovascular Morbidity after Early Term Birth

There is accumulating evidence that the consequences of even late preterm birth (34-37 weeks of gestation) reach well beyond the neonatal hospitalization into morbidities commonly seen in adulthood. The Barker hypothesis proposed that fetal adaptations to suboptimal intrauterine oxygen and nutrient supply result in changes in physiology and metabolism that subsequently predispose these individuals to an increased risk of cardiovascular diseases over their lifetime, including ischemic heart disease, stroke, diabetes, and hypertension.

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