Gastroscopy and gastric cancer–related mortality: Time to change recommendations regarding screening?

Gastric cancer is the third most common cause of cancer-related death worldwide,1 and most cases are locally advanced or metastatic at diagnosis. Widespread Helicobacter pylori eradication2 and radiologic or endoscopic screening,3 have been proved to decrease gastric cancer mortality in high-incidence countries. However, in countries with lower incidence, these strategies are probably not cost effective, and there are only recommendations regarding secondary prevention in high-risk patients, such as those with gastric preneoplastic conditions.

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