Endoscopic eradication therapy and the test of time

Endoscopic therapy for Barrett's esophagus (BE) has come a long way since 1992, when Brandt and Kauvar1 first demonstrated that BE metaplasia could be ablated by using endoscopically delivered laser irradiation. Early concerns regarding the feasibility and safety of endoscopic therapy were soon allayed, and attention shifted to finding the best endoscopic eradication technique. Endoscopic ablative modalities that have been studied include a variety of laser types, multipolar electrocoagulation, argon plasma coagulation, photodynamic therapy, radiofrequency ablation (RFA), and cryotherapy.

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