Building Predictive Models of Genetic Circuits Using the Principle of Maximum Caliber

Learning the underlying details of a gene network is a major challenge in cellular and synthetic biology. We address this challenge by building a chemical kinetic model that utilizes information encoded in the stochastic protein expression trajectories typically measured in experiments. The applicability of the proposed method is demonstrated in an auto-activating genetic circuit, a common motif in natural and synthetic gene networks. Our approach is based on the principle of maximum caliber (MaxCal)—a dynamical analog of the principle of maximum entropy—and builds a minimal model using only three constraints: 1) protein synthesis, 2) protein degradation, and 3) positive feedback.

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