Association of Total Cholesterol, Low-Density Lipoprotein Cholesterol, and Non-High-Density Lipoprotein Cholesterol with Atherosclerotic Cardiovascular Disease and Cancer in a Chinese Male Population

Abstract

Objective

The objective of this study was to investigate the association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) with atherosclerotic cardiovascular disease (ASCVD) or cancer in a male population in the Kailuan cohort of China.

Methods

This prospective study included 68,769 Chinese male adults from Kailuan cohort of China who had a standardized medical examination between 2006 and 2007 and were followed up for approximately 8 years until occurrence of ASCVD, cancer or death or until December 31, 2014. Cox regression models were used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs). Multivariable analysis was adjusted for age, cigarette smoking, alcohol consumption, physical activity, hypertension, diabetes mellitus and BMI at baseline.

Results

During follow-up, 2,916 males developed ASCVD and 1,884 developed cancer. Compared with the lowest quartile, the upper-most quartiles of TC, LDL-C and non-HDL-C were all associated with increased ASCVD risk (HR 1.53, 95% CI 1.37-1.70; HR 1.16, 95% CI 1.05-1.28; HR 1.55, 95% CI 1.39-1.72); however, the upper-most quartiles of TC, LDL-C and non-HDL-C were all negatively associated with cancer (HR 0.84, 95% CI 0.74-0.95; HR 0.82, 95% CI 0.72-0.93; HR 0.80, 95%CI 0.70-0.90) and these associations were present after exclusion of incident cancers during the first 4 years of follow-up.

Conclusion

In this Kailuan cohort study, we report that high TC, LDL-C and non-HDL-C concentrations increased ASCVD incidence in a male population and that these lipid profiles were inversely associated with total cancer and several individual cancers. This article is protected by copyright. All rights reserved.

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