Neuroprotective Strategies in Neonatal Brain Injury

The developing brain responds to injury in a gestational age–dependent manner. During the third trimester, white matter injury is most common, whereas in infants born at term, gray matter injury predominates. Together, prematurity and hypoxic ischemic encephalopathy (HIE) account for 50% of global neonatal mortality, as well as significant neurodevelopmental impairment in survivors. In fact, the neonatal mortality from birth asphyxia is under-reported, as many affected infants in resource-limited settings are not resuscitated and are reported as stillborn.

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