The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding

Wang and colleagues show that the primate-specific gene TMEM14B marks a subset of human neural progenitors and induces cortical folding, providing insights into human brain evolution. Expressing TMEM14B in the fetal mouse brain increases proliferation of progenitor subsets and cortical thickening through nuclear shuttling of IQGAP1, which promotes G1/S transitions.

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