Lung disease caused by Mycobacterium abscessus is increasing and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro. Synergy was found with an FICI ≤ 0.5 and a 4 to 10-fold decrease of minimum inhibitory concentrations.
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