Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption [PublishAheadOfPrint]

Pseudomonas aeruginosa biofilms contribute to its survival on biotic and abiotic surfaces and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the discovery of anti-biofilm agents may hold great promise. We show that pharmacological inhibition of the P. aeruginosa quorum sensing regulator MvfR (PqsR) using a benzamide-benzimidazole compound interferes with biofilm formation and potentiates biofilm sensitivity to antibiotics. Such a strategy could have a great potential against P. aeruginosa persistence in diverse environments.

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