Re: Association of inflammatory cytokines with the symptom cluster of pain, fatigue, depression, and sleep disturbance in Chinese patients with cancer

Ji et al examined the association between inflammatory cytokines and cluster symptoms on pain, fatigue, depression, and sleep disturbance in patients with cancer.1 Multiple logistic regression analysis was applied in 153 in-patients with cancer, composed of 125 patients with all low symptoms (subgroup 1) and 28 patients with moderate-to-high symptoms on 4 items (subgroup 3). Adjusted odds ratios (95% confidence intervals) of subgroup 3 against subgroup 1 for increased serum interleukin-6 level and poorer Eastern Cooperative Oncology Group (ECOG) physical performance status were 1.246 (1.114-1.394) and 31.831 (6.017-168.385), respectively.

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