Analysis of chromatin opening in heterochromatic non-small cell lung cancer tumour initiating cells in relation to DNA damaging anti-tumour treatment

We investigated the involvement of chromatin structure in the context of non-small cell lung cancer tumour initiating cells, an aspect few studies have addressed. We have explored the efficacy of histone deacetylase inhibitors in targeting this cell population, alone or in combination with radiation/cisplatin. Heterochromatin structure seem to play a role in therapy resistance of these tumour initiating cells, which is especially interesting since these inhibitors are clinically available and heterochromatin marker selection is possible.

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