Issue highlights

Patients with cirrhosis have been shown to have a decrease in health-related quality of life (HRQOL). These patients also report sleep disturbances, which can negatively affect HRQOL. In this issue of Clinical Gastroenterology and Hepatology, Ghabril and colleagues measured the prevalence of disturbed sleep and its impact on HRQOL in 193 ambulatory patients with cirrhosis. Of these, 154 patients had decompensated cirrhosis but did not have any evidence of overt hepatic encephalopathy. The authors also compared neurocognitive function, actigraphy (measuring sleep time, latency, awakenings), and non-targeted serum metabolic profiling in subsets of patients with normal and disturbed sleep.

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