BioEssays 7∕2017

Interindividual epigenetic variability: Sound or noise? This cover image tries to reflect the potential consequences of epigenetic "sound" (purposeful epigenetic changes) and epigenetic "noise" (stochastic epigenetic changes) in the establishment of interindividual epigenetic variability. The different DNA molecules make allusion to different individuals, where musical notes represent methylathed (minim) and unmethylated (crotchet) CpGs, introducing the concept of phenotypic variation across the population of interest. To highlight the idea of "purposeful" and "stochastic" epigenetic variation, DNA molecules are split into a clean, easy to interpret signal (left side), or a blurry, noisy pattern (right side) respectively, reflecting some of the current biological scenarios that are discussed in article 1700055 by Juan Ramón Tejedor and Mario F. Fraga.

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