Does Antipyresis Improve Mortality in Critically Ill Septic Patients?

The authors included 8 randomized controlled trials for analysis, 4 of which assessed 28-day mortality and 4 of which assessed inhospital mortality (Table). In total, the review included 1,531 patients, 1,507 of whom were included for analysis of the primary outcome. Pooled data analysis found similar 28-day or inhospital mortality rates between patients receiving and not receiving antipyretics (RR 0.93; 95% CI 0.79 to 1.09). Analyses of secondary outcomes demonstrated that patients receiving antipyretics experienced lower 14-day mortality (RR 0.68; 95% CI 0.49 to 0.92) and postintervention body temperature (mean difference –0.38°C [–68°F]; 95% CI –0.63 [–1.13°F] to –0.13°C [–0.23°F]).

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