Reversal of long term potentiation-like plasticity in primary motor cortex in patients with progressive supranuclear palsy

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder due to the deposition of tau-protein aggregates in several brain regions leading to parkinsonism, oculomotor abnormalities, early postural instability and falls. To date, the pathophysiological mechanisms of PSP are still poorly understood (Colosimo et al., 2014; Wenning et al., 2013).

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