MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease

Publication date: Available online 24 March 2016
Source:Free Radical Biology and Medicine
Author(s): Shelly C Lu, José M. Mato, Cristina Espinosa-Diez, Santiago Lamas
The discovery of the microRNA (miRNA) family of small RNAs as fundamental regulators of post-transcriptional gene expression has fostered research on their importance in every area of biology and clinical medicine. In the particular area of liver metabolism and disease, miRNAs are gaining increasing importance. By focusing on two fundamental hepatic biosynthetic pathways, glutathione and methionine, we review recent advances on the comprehension of the role of miRNAs in liver pathophysiology and more specifically of models of hepatic cholestasis/fibrosis and hepatocellular carcinoma.



from #Medicine via ola Kala on Inoreader http://ift.tt/1LK7xOE
via IFTTT