It is well recognized that regulating the hair follicle cycle in association with Wnt signaling is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether selected herbal medicines processed by decoction and fermentation promote hair growth by upregulating the number and size of hair follicles and Wnt signaling, including activation of β-catenin and Akt in telogen-synchronized C57BL/6N mice. The results revealed that the fermented extract after decoction (FDE) more effectively promoted hair growth than that of a nonfermented extract (DE). Notably, FDE effectively enhanced formation of hair follicles with clearer differentiation between the inner and outer root sheath, which is observed during the anagen phase. Mechanistic evidence was found for increased β-catenin and Akt phosphorylation levels in dorsal skin tissue along with elevated expression of hair regrowth-related genes, such as Wnt3/10a/10b, Lef1, and fibroblast growth factor 7. In conclusion, our findings suggest that FDE plays an important role in regulating the hair cycle by increasing expression of hair regrowth-related genes and activating downstream Wnt signaling targets.
from #Medicine via ola Kala on Inoreader http://ift.tt/1MEGMpI
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαρτίου
(699)
-
▼
Μαρ 24
(51)
- An analysis of baseline data from the PROUD study:...
- Supporting Treatment Adherence Readiness through T...
- Comparison of exenatide with biphasic insulin aspa...
- Morita therapy for depression and anxiety (Morita ...
- A case report of immunosuppression-related Kaposi’...
- Blinding in randomized controlled trials in genera...
- High Throughput Assay to Examine Egg-Laying Prefer...
- Correlation of serum PCSK9 in CHD patients with th...
- Clinical observation on pericardiocentesis and glu...
- Assessment of cardiac arrhythmias in patients with...
- USP4 promotes invasion of breast cancer cells via ...
- MicroRNA-138 inhibits proliferation of cervical ca...
- Impact of Aging on Mitochondrial Function in Cardi...
- Inhibition of the JNK signaling pathway increases ...
- Mechanism of action of EBV, Bcl-2, p53, c-Myc and ...
- DTC chemotherapy regimen is associated with higher...
- Decoction and Fermentation of Selected Medicinal H...
- MicroRNA-mediated regulation of glutathione and me...
- Association between pain catastrophising and muscu...
- More From Less: High-Throughout Dual Polarity Lipi...
- Raman spectroscopy as a tool for label-free lympho...
- High level of chemokine CCL18 is associated with p...
- Early Mobilization and Rehabilitation of the Criti...
- Temporary IVC Filters: How Do We Move Forward?
- Hypertension is associated with undiagnosed obstru...
- Oropharyngeal crowding closely relates to aggravat...
- Effect of Continuous Positive Airway Pressure on C...
- A Multidisciplinary Pulmonary Embolism Response Te...
- Recent Advances in Chest Medicine: Advances in Bro...
- Elevated levels of circulating BMP7 predict mortal...
- Inside front cover continued (editorial board memb...
- Editorial board
- Deficient Aversive-potentiated Startle and the Tri...
- Impact of migration on tuberculosis epidemiology a...
- Epidemiological characteristics and risk factors o...
- Migration-related tuberculosis: epidemiology and c...
- Increased incidence of invasive meningococcal dise...
- The effect of migration within the European Union/...
- Presentation with gastrointestinal symptoms and hi...
- WHO publishes an implementation framework on activ...
- Diagnostic Utility of Neuregulin for Acute Coronar...
- MicroRNA-138 regulates chemoresistance in human no...
- Silencing of NUF2 inhibits proliferation of human ...
- Advance in the study on p38 MAPK mediated drug res...
- PRAME promotes in vitro leukemia cells death by re...
- Prioritization of high-cost new drugs for HCV: how...
- Quantitative fibrosis parameters highly predict es...
- Characteristic analysis of white matter lesions in...
- Nesfatin-1 hormone levels in morbidly obese patien...
- The association of vascular endothelial growth fac...
- Polymers, Vol. 8, Pages 91: Drug Delivery Systems ...
-
▼
Μαρ 24
(51)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 24 Μαρτίου 2016
Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.