Elevated levels of circulating BMP7 predict mortality in pulmonary arterial hypertension

Background

This study aimed to show whether circulating BMPs levels are associated with increased risk of mortality in PAH patients.

Methods

A total of 156 PAH patients including 43 HPAH and 113 IPAH diagnosed by gene screening were enrolled in the study. Circulating BMPs were measured by ELISA in plasma samples from HPAH (n = 43), IPAH (n = 113) and controls (n = 51). Clinical characteristics at baseline and long-term survival were compared according to the different BMPs levels.

Results

HPAH patients had significantly higher BMP7 concentrations than IPAH and controls (20.1 (9.4, 55.2) vs. 6.5 (3.5, 11.7) and 2.5 (0.9, 6.6) pg/ml, respectively; P Conclusions

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