Publication date: 15 April 2016
Source:Bioorganic & Medicinal Chemistry, Volume 24, Issue 8
Author(s): Atilla Akdemir, Özlen Güzel-Akdemir, Nilgün Karalı, Claudiu T. Supuran
Enzyme inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1) from pathogenic Candida species (CaNce103 from C. albicans and CgNce103 from C. glabrata). The compounds show KI values in the low nanomolar range for the fungal CAs, while they have significantly higher KI values for the human CAs. Homology models were constructed for the CaNce103 and CgNce103 and subsequently the ligands were docked into these models to rationalize their enzyme inhibitory properties.
Graphical abstract
from #Medicine via ola Kala on Inoreader http://ift.tt/1RDNkwj
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.