Exercise training as a drug to treat age associated frailty

Publication date: Available online 25 March 2016
Source:Free Radical Biology and Medicine
Author(s): Jose Viña, Andrea Salvador-Pascual, Francisco Jose Tarazona-Santabalbina, Leocadio Rodriguez-Mañas, Mari Carmen Gomez-Cabrera
Exercise causes an increase in the production of free radicals [1]. As a result of a hormetic mechanism antioxidant enzymes are synthesized and the cells are protected against further oxidative stress. Thus, exercise can be considered as an antioxidant [2]. Age-associated frailty is a major medical and social concern as it can easily lead to dependency.In this review we describe that oxidative stress is associated with frailty and the mechanism by which exercise prevents age-associated frailty. We propose that individually tailored multicomponent exercise programmes are one of the best ways to prevent and to treat age-associated frailty.



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