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Τρίτη 2 Φεβρουαρίου 2016

Impact of a publicly funded monovalent rotavirus vaccination program in the Province of Quebec (Canada)

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Publication date: 10 February 2016
Source:Vaccine, Volume 34, Issue 7
Author(s): Jeannette L. Comeau, Arnaud Gagneur, Caroline Quach
In November 2011, the province of Quebec, Canada implemented a publicly funded rotavirus (RV) vaccination program using the monovalent RV vaccine (RV1). To assess its impact, trends in passive RV laboratory detection and Emergency Department (ED) visits for gastroenteritis (GE) at two pediatric centers were evaluated.MethodsRV tests performed were extracted from the virology laboratory databases and ED visits for GE between July 1, 2006 and June 30, 2013, from the ED databases of The Montreal Children's Hospital (MCH) and Centre Hospitalier Universitaire de Sherbrooke (CHUS). The percent positive RV tests over time and season duration were assessed using 5-week moving averages. We defined season start and end as the first two and the last two consecutive weeks where the percent positive RV tests were ≥10%, respectively.ResultsComparing the pre- and post-vaccination program periods, a decrease in the proportion of positive RV tests was seen: 15.9% vs. 5.1% (p<0.001). Pre-vaccination program, RV seasons started between December and February, peaked in March or April and ended in May. In 2011–2012, the season started in March, peaked in April, and ended in May. In 2012–2013, the season lasted 3 weeks in May. ED visits for GE decreased post-introduction of the RV1 program: from 4.8% to 3.4% in 2011–2012, and 4.2% in 2012–13 (p<0.001). In children <2 years of age, ED GE visits decreased from 7.5% to 4.8% in 2011–2012, and 5.2% in 2012–2013 (p<0.001). Admissions for GE also decreased significantly from 0.41% of all ED visits to 0.14% in 2011–2012 and 0.22% in 2012–2013 (p<0.005).ConclusionImplementation of a publicly funded RV vaccination program had a major impact on the epidemiology of RV infections in Quebec: RV seasons have started later and been of shorter duration, peak positives were fewer, and ED visits for GE decreased.



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