Highly pathogenic H5N1 infections are often accompanied by excessive pro-inflammatory response, high viral titer, and apoptosis; as such, the efficient control of these infections poses a great challenge. The pathogenesis of influenza virus infection is also related to oxidative stress. However, the role of endogenic genes with antioxidant effect in the control of influenza viruses, especially H5N1 viruses, should be further investigated. In this study, the H5N1 infection in lung epithelial cells decreased Cu/Zn superoxide dismutase (SOD1) expression at mRNA and protein levels. Forced SOD1 expression significantly inhibited the H5N1-induced increase in reactive oxygen species, decreased pro-inflammatory response, prevented p65 and p38 phosphorylation, and impeded viral ribonucleoprotein nuclear export and viral replication. The SOD1 overexpression also rescued H5N1-induced cellular apoptosis and alleviated H5N1-caused mitochondrial dysfunction. Therefore, this study described the role of SOD1 in the replication of H5N1 influenza virus and emphasized the relevance of this enzyme in the control of H5N1 replication in epithelial cells. Pharmacological modulation or targeting SOD1 may open a new way to fight H5N1 influenza virus.
from #Medicine via ola Kala on Inoreader http://ift.tt/1TJsSHd
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 08
(50)
- Local and global visual processing and eating diso...
- Comparison of RNA extraction kits and histological...
- Rapid Identification of Pseudomonas spp. via Raman...
- Highly Sensitive Laser Scanning of Photon-Upconver...
- Environment-Sensitive Fluorescent Probe for the Hu...
- Disulfide Linkage Characterization of Disulfide Bo...
- Analysis of Chain Branch of Polyolefins by a New P...
- Cost-Effectiveness of Ranibizumab Versus Afliberce...
- Imaging Local Electric Field Distribution by Plasm...
- Sequential learning of psychomotor and visuospatia...
- Infrared and Raman screening of seized Novel Psych...
- Optional Sub-study to Intraoperative Imaging With ...
- Mitochondrial Respiratory Function in Mammalian Sk...
- Exosome Testing as a Screening Modality for Human ...
- A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®...
- Metals, Vol. 6, Pages 15: Casting Alloy Design and...
- Metals, Vol. 6, Pages 14: Effective Synthesis and ...
- Photonics, Vol. 3, Pages 4: Design and Analysis of...
- Metabolites, Vol. 6, Pages 2: Using Molecular Netw...
- Nutrients, Vol. 8, Pages 31: Association of Dietar...
- Materials, Vol. 9, Pages 34: Aminopropyl-Silica Hy...
- JoF, Vol. 2, Pages 5: Pediatric Invasive Candidias...
- Marine Drugs, Vol. 14, Pages 14: Anti-Inflammatory...
- Nanomaterials, Vol. 6, Pages 13: White Light-Emitt...
- Nanomaterials, Vol. 6, Pages 12: The Coupled Photo...
- Materials, Vol. 9, Pages 33: A Critical Evaluation...
- Energies, Vol. 9, Pages 36: Developing a New HSR S...
- Symmetry, Vol. 8, Pages 2: Natural Abundance Isoto...
- Children, Vol. 3, Pages 1: Learning Lessons from A...
- Toxics, Vol. 4, Pages 1: Farmers’ Exposure to Pest...
- Annual Review of Cybertherapy and Telemedicine 2015
- Researchers Face Potential Danger from Protein Par...
- Study finds cerebrovascular disease to be major de...
- Water, Vol. 8, Pages 18: A Reliability Analysis of...
- Viruses, Vol. 8, Pages 13: The Influenza Virus H5N...
- Entropy, Vol. 18, Pages 22: Increment Entropy as a...
- Animals, Vol. 6, Pages 5: Welfare Conditions of Do...
- Viruses, Vol. 8, Pages 14: Metaviromics of Namib D...
- Buildings, Vol. 6, Pages 3: Assessment of the Perf...
- Entropy, Vol. 18, Pages 23: Long Range Dependence ...
- IJERPH, Vol. 13, Pages 116: Regional Differences i...
- IJERPH, Vol. 13, Pages 113: Unemployment Rate, Smo...
- IJERPH, Vol. 13, Pages 115: Descriptive Characteri...
- Cancer cell identification by bi-color ZnO and TiO...
- Real-time endoscopic Raman spectroscopy for in viv...
- IJMS, Vol. 17, Pages 77: Revealing the Effects of ...
- IJMS, Vol. 17, Pages 72: MiRNA-Target Interaction ...
- IJMS, Vol. 17, Pages 71: Anti-Oncogenic gem-Dihydr...
- IJMS, Vol. 17, Pages 76: Antiproliferative Activit...
- IJMS, Vol. 17, Pages 73: NLRP3 Upregulation in Ret...
-
▼
Ιαν 08
(50)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 8 Ιανουαρίου 2016
Viruses, Vol. 8, Pages 13: The Influenza Virus H5N1 Infection Can Induce ROS Production for Viral Replication and Host Cell Death in A549 Cells Modulated by Human Cu/Zn Superoxide Dismutase (SOD1) Overexpression
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.