The oceans represent an understudied resource for the isolation of bacteria with the potential to produce novel secondary metabolites. In particular, actinomyces are well known to produce chemically diverse metabolites with a wide range of biological activities. This study characterised spore-forming bacteria from both Scottish and Antarctic sediments to assess the influence of isolation location on secondary metabolite production. Due to the selective isolation method used, all 85 isolates belonged to the phyla Firmicutes and Actinobacteria, with the majority of isolates belonging to the genera Bacillus and Streptomyces. Based on morphology, thirty-eight isolates were chosen for chemical investigation. Molecular networking based on chemical profiles (HR-MS/MS) of fermentation extracts was used to compare complex metabolite extracts. The results revealed 40% and 42% of parent ions were produced by Antarctic and Scottish isolated bacteria, respectively, and only 8% of networked metabolites were shared between these locations, implying a high degree of biogeographic influence upon secondary metabolite production. The resulting molecular network contained over 3500 parent ions with a mass range of m/z 149–2558 illustrating the wealth of metabolites produced. Furthermore, seven fermentation extracts showed bioactivity against epithelial colon adenocarcinoma cells, demonstrating the potential for the discovery of novel bioactive compounds from these understudied locations.
from #Medicine via ola Kala on Inoreader http://ift.tt/1OfHuu6
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 08
(50)
- Local and global visual processing and eating diso...
- Comparison of RNA extraction kits and histological...
- Rapid Identification of Pseudomonas spp. via Raman...
- Highly Sensitive Laser Scanning of Photon-Upconver...
- Environment-Sensitive Fluorescent Probe for the Hu...
- Disulfide Linkage Characterization of Disulfide Bo...
- Analysis of Chain Branch of Polyolefins by a New P...
- Cost-Effectiveness of Ranibizumab Versus Afliberce...
- Imaging Local Electric Field Distribution by Plasm...
- Sequential learning of psychomotor and visuospatia...
- Infrared and Raman screening of seized Novel Psych...
- Optional Sub-study to Intraoperative Imaging With ...
- Mitochondrial Respiratory Function in Mammalian Sk...
- Exosome Testing as a Screening Modality for Human ...
- A Phase Ib Trial of Concurrent Cetuximab (ERBITUX®...
- Metals, Vol. 6, Pages 15: Casting Alloy Design and...
- Metals, Vol. 6, Pages 14: Effective Synthesis and ...
- Photonics, Vol. 3, Pages 4: Design and Analysis of...
- Metabolites, Vol. 6, Pages 2: Using Molecular Netw...
- Nutrients, Vol. 8, Pages 31: Association of Dietar...
- Materials, Vol. 9, Pages 34: Aminopropyl-Silica Hy...
- JoF, Vol. 2, Pages 5: Pediatric Invasive Candidias...
- Marine Drugs, Vol. 14, Pages 14: Anti-Inflammatory...
- Nanomaterials, Vol. 6, Pages 13: White Light-Emitt...
- Nanomaterials, Vol. 6, Pages 12: The Coupled Photo...
- Materials, Vol. 9, Pages 33: A Critical Evaluation...
- Energies, Vol. 9, Pages 36: Developing a New HSR S...
- Symmetry, Vol. 8, Pages 2: Natural Abundance Isoto...
- Children, Vol. 3, Pages 1: Learning Lessons from A...
- Toxics, Vol. 4, Pages 1: Farmers’ Exposure to Pest...
- Annual Review of Cybertherapy and Telemedicine 2015
- Researchers Face Potential Danger from Protein Par...
- Study finds cerebrovascular disease to be major de...
- Water, Vol. 8, Pages 18: A Reliability Analysis of...
- Viruses, Vol. 8, Pages 13: The Influenza Virus H5N...
- Entropy, Vol. 18, Pages 22: Increment Entropy as a...
- Animals, Vol. 6, Pages 5: Welfare Conditions of Do...
- Viruses, Vol. 8, Pages 14: Metaviromics of Namib D...
- Buildings, Vol. 6, Pages 3: Assessment of the Perf...
- Entropy, Vol. 18, Pages 23: Long Range Dependence ...
- IJERPH, Vol. 13, Pages 116: Regional Differences i...
- IJERPH, Vol. 13, Pages 113: Unemployment Rate, Smo...
- IJERPH, Vol. 13, Pages 115: Descriptive Characteri...
- Cancer cell identification by bi-color ZnO and TiO...
- Real-time endoscopic Raman spectroscopy for in viv...
- IJMS, Vol. 17, Pages 77: Revealing the Effects of ...
- IJMS, Vol. 17, Pages 72: MiRNA-Target Interaction ...
- IJMS, Vol. 17, Pages 71: Anti-Oncogenic gem-Dihydr...
- IJMS, Vol. 17, Pages 76: Antiproliferative Activit...
- IJMS, Vol. 17, Pages 73: NLRP3 Upregulation in Ret...
-
▼
Ιαν 08
(50)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 8 Ιανουαρίου 2016
Metabolites, Vol. 6, Pages 2: Using Molecular Networking for Microbial Secondary Metabolite Bioprospecting
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.