Cancer cell identification by bi-color ZnO and TiO2 nanowires

Semiconductor nanocomposites provide advantages beyond the capability of typical fluorescent materials for cancer detection. In this work, nanowire-based probes with dual color channels are employed to demonstrate the capacity of cancer cell detection. Purple emitting ZnO/antibody probes are applied to detect cancer cells and meanwhile TiO₂/antibody probes with green light emission are applied to identify normal fibroblast cells. A series of quantitative analyses are conducted to verify the correlation between the concentrations of ZnO and TiO₂ probes, cell numbers, and peak intensities of the PL spectra. The results provide a quantitative reference for developing nanowire-based cancel cell probes.

The microscopic image of the co-cultured SCC and HS68 cells which are applied with ZnO-EGFR and TiO₂-Vimentin nanoprobes under the illumination of a laser. Among them, purple emission from ZnO, green emission from TiO₂ can be seen. The position of SCC and Hs68 cells can be easily verified with the help of the two probes.

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