Publication date: December 2015
Source:Neoplasia, Volume 17, Issue 12
Author(s): Grazyna Mosieniak, Malgorzata A. Sliwinska, Olga Alster, Anna Strzeszewska, Piotr Sunderland, Malgorzata Piechota, Halina Was, Ewa Sikora
Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is postulated that polyploidization of cancer cells is connected with disease relapse. We postulate that cancer cell polyploidization associated with senescence is the culprit of atypical cell divisions leading to cancer cell regrowth. Accordingly, we aimed to dissociate between these two phenomena. We induced senescence in HCT 116 cells by pulse treatment with doxorubicin and observed transiently increased ploidy, abnormal nuclear morphology, and various distributions of some proteins (e.g., p21, Ki-67, SA-β-galactosidase) in the subnuclei. Doxorubicin-treated HCT 116 cells displayed an increased production of reactive oxygen species (ROS) possibly caused by an increased amount of mitochondria, which are characterized by low membrane potential. A decrease in the level of ROS by Trolox partially protected the cells from polyploidization but not from senescence. Interestingly, a decreased level of ROS prevented the cells from escaping senescence. We also show that MCF7 cells senesce, but this is not accompanied by the increase of ploidy upon doxorubicin treatment. Moreover, they were stably growth arrested, thus proving that polyploidy but not senescence per se enables to regain the ability to proliferate. Our preliminary results indicate that the different propensity of the HCT 116 and MCF7 cells to increase ploidy upon cell senescence could be caused by a different level of the mTOR and/or Pim-1 kinases.
from #Medicine via ola Kala on Inoreader http://ift.tt/1YeIB1N
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 14
(64)
- Review of Surface Enhanced Raman Scattering Applic...
- Simultaneous detection of single-nucleotide polymo...
- In vitro antiviral activity against rotavirus and ...
- Characterization of mannanase from Bacillus circul...
- Predicting the risk of sudden cardiac death
- TRPM7 kinase activity regulates murine mast cell d...
- Predicting drug-induced QT prolongation and torsad...
- Sex differences in vascular endothelial function a...
- Supersensitive and selective detection of picric a...
- Mass spectrometry of modified RNAs: recent develop...
- Probing DNA-stabilized fluorescent silver nanoclus...
- Emulsion technologies for multicellular tumour sph...
- Tualang Honey Protects against BPA-Induced Morphol...
- Breast Cancer Cell Colonization of the Human Bone ...
- In Vivo Autofluorescence Imaging of Tumor Heteroge...
- Combining Optical Reporter Proteins with Different...
- Polyploidy Formation in Doxorubicin-Treated Cancer...
- Table of Contents
- Genetic Variations in Inflammatory Response Genes ...
- Can Healthcare Assistant Training (CHAT) improve t...
- IJMS, Vol. 16, Pages 29797-29814: The Mechanisms o...
- IJMS, Vol. 16, Pages 29787-29796: Identification o...
- Genotyping HLA-B*5801 for Allopurinol-Induced Seve...
- Highly CO2 sensitive extruded fluorescent plastic ...
- IJERPH, Vol. 12, Pages 15860-15874: Autonomic Nerv...
- Catalysts, Vol. 5, Pages 2134-2146: Facile Synthes...
- JDB, Vol. 3, Pages 129-157: Cell Fate Decision Mak...
- Fibers, Vol. 3, Pages 539-559: The Influence of CF...
- Agriculture, Vol. 5, Pages 1277-1288: Selenium Bio...
- Cancers, Vol. 7, Pages 2459-2465: Acute Myeloid Le...
- Biomolecules, Vol. 5, Pages 3448-3466: On the Role...
- Biosensors, Vol. 5, Pages 768-790: High Content Im...
- Information, Vol. 6, Pages 866-879: Codeword Struc...
- JSAN, Vol. 4, Pages 378-409: The Efficacy of Epide...
- Metals, Vol. 5, Pages 2383-2392: A Simple Up-Scala...
- Marine Drugs, Vol. 13, Pages 7390-7402: Algal Toxi...
- Membranes, Vol. 5, Pages 915-923: NMR Studies of S...
- Resources, Vol. 4, Pages 939-957: A Standard Chara...
- IJMS, Vol. 16, Pages 29797-29814: The Mechanisms o...
- Glucose transporters 1, 3, 6, and 10 are expressed...
- Enteral feeding therapy for maintaining remission ...
- Modeling the ecologic niche of plague in sylvan an...
- Evaluating pharmacological models of high and low ...
- Emerging semantics to link phenotype and environment
- Analysis of synonymous codon usage patterns in six...
- Specific labeling: An effective tool to explore th...
- Sensors, Vol. 15, Pages 31464-31481: Probabilistic...
- Sensors, Vol. 15, Pages 31482-31524: Robust 3D Pos...
- Sensors, Vol. 15, Pages 31442-31452: Multiple-Para...
- Viruses, Vol. 7, Pages 6604-6612: Recent Advances ...
- Uncommon Trimethoxylated Flavonol Obtained from Ru...
- The Preventive Effect on Ethanol-Induced Gastric L...
- Effectiveness of legislative changes obligating no...
- Extended follow-up of lung cancer and non-malignan...
- Pesticide use and risk of end-stage renal disease ...
- Ambient air pollution and risk of tuberculosis: a ...
- World Trade Center-related physical and mental hea...
- Agricultural pesticide exposure and chronic kidney...
- Incidence and mortality risks for circulatory dise...
- Heavy lifting at work and risk of retinal detachme...
- The joint effect of asbestos exposure, tobacco smo...
- Effectiveness of workplace interventions in the pr...
- Exposure to loud noise, bilateral high-frequency h...
- Author response: Extended follow-up of lung cancer...
-
▼
Δεκ 14
(64)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 14 Δεκεμβρίου 2015
Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.