Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and death. Although it is well known that azaspiracid-1 is toxic to most cells and cell lines, little is known about its biological target(s). A rat PC12 cell line, commonly used as a model for the peripheral nervous system, was used to study the neurotoxicological effects of azaspiracid-1. Azaspiracid-1 induced differentiation-related morphological changes followed by a latter cell death. The differentiated phenotype showed peripherin-labelled neurite-like processes simultaneously as a specific isoform of peripherin was down-regulated. The precise mechanism behind this down-regulation remains uncertain. However, this study provides new insights into the neurological effects of azaspiracid-1 and into the biological significance of specific isoforms of peripherin.
from #Medicine via ola Kala on Inoreader http://ift.tt/1Uo8D2d
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 14
(64)
- Review of Surface Enhanced Raman Scattering Applic...
- Simultaneous detection of single-nucleotide polymo...
- In vitro antiviral activity against rotavirus and ...
- Characterization of mannanase from Bacillus circul...
- Predicting the risk of sudden cardiac death
- TRPM7 kinase activity regulates murine mast cell d...
- Predicting drug-induced QT prolongation and torsad...
- Sex differences in vascular endothelial function a...
- Supersensitive and selective detection of picric a...
- Mass spectrometry of modified RNAs: recent develop...
- Probing DNA-stabilized fluorescent silver nanoclus...
- Emulsion technologies for multicellular tumour sph...
- Tualang Honey Protects against BPA-Induced Morphol...
- Breast Cancer Cell Colonization of the Human Bone ...
- In Vivo Autofluorescence Imaging of Tumor Heteroge...
- Combining Optical Reporter Proteins with Different...
- Polyploidy Formation in Doxorubicin-Treated Cancer...
- Table of Contents
- Genetic Variations in Inflammatory Response Genes ...
- Can Healthcare Assistant Training (CHAT) improve t...
- IJMS, Vol. 16, Pages 29797-29814: The Mechanisms o...
- IJMS, Vol. 16, Pages 29787-29796: Identification o...
- Genotyping HLA-B*5801 for Allopurinol-Induced Seve...
- Highly CO2 sensitive extruded fluorescent plastic ...
- IJERPH, Vol. 12, Pages 15860-15874: Autonomic Nerv...
- Catalysts, Vol. 5, Pages 2134-2146: Facile Synthes...
- JDB, Vol. 3, Pages 129-157: Cell Fate Decision Mak...
- Fibers, Vol. 3, Pages 539-559: The Influence of CF...
- Agriculture, Vol. 5, Pages 1277-1288: Selenium Bio...
- Cancers, Vol. 7, Pages 2459-2465: Acute Myeloid Le...
- Biomolecules, Vol. 5, Pages 3448-3466: On the Role...
- Biosensors, Vol. 5, Pages 768-790: High Content Im...
- Information, Vol. 6, Pages 866-879: Codeword Struc...
- JSAN, Vol. 4, Pages 378-409: The Efficacy of Epide...
- Metals, Vol. 5, Pages 2383-2392: A Simple Up-Scala...
- Marine Drugs, Vol. 13, Pages 7390-7402: Algal Toxi...
- Membranes, Vol. 5, Pages 915-923: NMR Studies of S...
- Resources, Vol. 4, Pages 939-957: A Standard Chara...
- IJMS, Vol. 16, Pages 29797-29814: The Mechanisms o...
- Glucose transporters 1, 3, 6, and 10 are expressed...
- Enteral feeding therapy for maintaining remission ...
- Modeling the ecologic niche of plague in sylvan an...
- Evaluating pharmacological models of high and low ...
- Emerging semantics to link phenotype and environment
- Analysis of synonymous codon usage patterns in six...
- Specific labeling: An effective tool to explore th...
- Sensors, Vol. 15, Pages 31464-31481: Probabilistic...
- Sensors, Vol. 15, Pages 31482-31524: Robust 3D Pos...
- Sensors, Vol. 15, Pages 31442-31452: Multiple-Para...
- Viruses, Vol. 7, Pages 6604-6612: Recent Advances ...
- Uncommon Trimethoxylated Flavonol Obtained from Ru...
- The Preventive Effect on Ethanol-Induced Gastric L...
- Effectiveness of legislative changes obligating no...
- Extended follow-up of lung cancer and non-malignan...
- Pesticide use and risk of end-stage renal disease ...
- Ambient air pollution and risk of tuberculosis: a ...
- World Trade Center-related physical and mental hea...
- Agricultural pesticide exposure and chronic kidney...
- Incidence and mortality risks for circulatory dise...
- Heavy lifting at work and risk of retinal detachme...
- The joint effect of asbestos exposure, tobacco smo...
- Effectiveness of workplace interventions in the pr...
- Exposure to loud noise, bilateral high-frequency h...
- Author response: Extended follow-up of lung cancer...
-
▼
Δεκ 14
(64)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 14 Δεκεμβρίου 2015
Marine Drugs, Vol. 13, Pages 7390-7402: Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.