α-Linolenic acid (ALA) is a nutraceutical found in vegetable products such as flax and walnuts. The pleiotropic properties of ALA target endogenous neuroprotective and neurorestorative pathways in brain and involve the transcription factor nuclear factor kappa B (NF-κB), brain-derived neurotrophic factor (BDNF), a major neuroprotective protein in brain, and downstream signaling pathways likely mediated via activation of TrkB, the cognate receptor of BDNF. In this review, we discuss possible mechanisms of ALA efficacy against the highly toxic OP nerve agent soman. Organophosphate (OP) nerve agents are highly toxic chemical warfare agents and a threat to military and civilian populations. Once considered only for battlefield use, these agents are now used by terrorists to inflict mass casualties. OP nerve agents inhibit the critical enzyme acetylcholinesterase (AChE) that rapidly leads to a cholinergic crisis involving multiple organs. Status epilepticus results from the excessive accumulation of synaptic acetylcholine which in turn leads to the overactivation of muscarinic receptors; prolonged seizures cause the neuropathology and long-term consequences in survivors. Current countermeasures mitigate symptoms and signs as well as reduce brain damage, but must be given within minutes after exposure to OP nerve agents supporting interest in newer and more effective therapies. The pleiotropic properties of ALA result in a coordinated molecular and cellular program to restore neuronal networks and improve cognitive function in soman-exposed animals. Collectively, ALA should be brought to the clinic to treat the long-term consequences of nerve agents in survivors. ALA may be an effective therapy for other acute and chronic neurodegenerative disorders.
from #Medicine via ola Kala on Inoreader http://ift.tt/20P4Gbl
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 12
(48)
- OtoRhinoLaryngology & Medicine,New Articles,Novemb...
- Reply to the Letter “Effect of anti-oxidant agents...
- Age-related effects on verbal and visuospatial mem...
- Molecules, Vol. 20, Pages 20341-20354: Direct Amin...
- Molecules, Vol. 20, Pages 20334-20340: Triterpenoi...
- Molecules, Vol. 20, Pages 20320-20333: Enhancement...
- Molecules, Vol. 20, Pages 20312-20319: Cytotoxic A...
- Molecules, Vol. 20, Pages 20355-20380: α-Linolenic...
- IJMS, Vol. 16, Pages 27072-27086: A Comparative St...
- IJMS, Vol. 16, Pages 27058-27071: Benzene-Induced ...
- IJMS, Vol. 16, Pages 27044-27057: Online Measureme...
- A predictive coding account of MMN reduction in sc...
- Successful cutting balloon angioplasty in a child ...
- Development of repeatable arrays of proteins using...
- Materials, Vol. 8, Pages 7650-7662: High Temperatu...
- Microorganisms, Vol. 3, Pages 866-889: Hydrogen Su...
- Microorganisms, Vol. 3, Pages 851-865: Bioactiviti...
- Molecules, Vol. 20, Pages 20297-20311: Derinat Pro...
- Materials, Vol. 8, Pages 7663-7672: Enhanced Erbiu...
- Prenatal diagnosis of single gene disorders using ...
- Identification of biomarkers to measure HIV-specif...
- Dynamics and role of antibodies to Plasmodium falc...
- Metals, Vol. 5, Pages 2119-2127: Liquid Phase Sepa...
- Metals, Vol. 5, Pages 2109-2118: Dynamic Strain Ev...
- Life, Vol. 5, Pages 1610-1628: Non-Standard Geneti...
- Life, Vol. 5, Pages 1587-1609: Starvation-Survival...
- Laws, Vol. 4, Pages 709-728: The Convention for th...
- Molecules, Vol. 20, Pages 20286-20296: β–Cyclodext...
- Effect of anti-oxidant agents in patients with hep...
- Healthcare, Vol. 3, Pages 1158-1173: The Applicati...
- Games, Vol. 6, Pages 604-636: The Role of Implicit...
- Entropy, Vol. 17, Pages 7680-7697: Using Expectati...
- Forests, Vol. 6, Pages 4088-4104: Characterization...
- Coatings, Vol. 5, Pages 830-864: The Search for Du...
- Coatings, Vol. 5, Pages 816-829: Natural Deposit C...
- Catalysts, Vol. 5, Pages 1928-1947: Molybdenum (VI...
- Catalysts, Vol. 5, Pages 1911-1927: Zr-SBA-15 Lewi...
- Catalysts, Vol. 5, Pages 1897-1910: Direct Convers...
- Biomolecules, Vol. 5, Pages 3142-3176: Immune Mech...
- Microarrays, Vol. 4, Pages 551-569: SNPs Array Kar...
- Applied Sciences, Vol. 5, Pages 1134-1163: An Effi...
- JDB, Vol. 3, Pages 93-111: Pbx4 is Required for th...
- Reproductive history and risk of cognitive impairm...
- Toxins, Vol. 7, Pages 4706-4729: Metabolism of Deo...
- Reasons & Symptoms of Dengue Fever
- Intra-individual lap time variation of the 400-m w...
- IJMS, Vol. 16, Pages 27032-27043: A PPO Promoter f...
- IJMS, Vol. 16, Pages 27015-27031: Sildenafil Prote...
-
▼
Νοε 12
(48)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 12 Νοεμβρίου 2015
Molecules, Vol. 20, Pages 20355-20380: α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.