A series of butylphthalide derivatives (BPDs) 1–8 were isolated from the extract of the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae). The cytotoxic activities of BPDs 1–8 were evaluated using a panel of human cancer cell lines. In addition, the SAR analysis and potential anti-invasion activities were investigated. The sp2 carbons at C-7 and C-7a appeared to be essential for the cytotoxic activities of BPDs. BPDs 5 and 6 remarkably inhibited the migration and invasion of cancer cells. The anti-invasion activity of dimer 6 was demonstrated to be significantly higher than monomer 5.
from #Medicine via ola Kala on Inoreader http://ift.tt/20P4Gbw
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 12
(48)
- OtoRhinoLaryngology & Medicine,New Articles,Novemb...
- Reply to the Letter “Effect of anti-oxidant agents...
- Age-related effects on verbal and visuospatial mem...
- Molecules, Vol. 20, Pages 20341-20354: Direct Amin...
- Molecules, Vol. 20, Pages 20334-20340: Triterpenoi...
- Molecules, Vol. 20, Pages 20320-20333: Enhancement...
- Molecules, Vol. 20, Pages 20312-20319: Cytotoxic A...
- Molecules, Vol. 20, Pages 20355-20380: α-Linolenic...
- IJMS, Vol. 16, Pages 27072-27086: A Comparative St...
- IJMS, Vol. 16, Pages 27058-27071: Benzene-Induced ...
- IJMS, Vol. 16, Pages 27044-27057: Online Measureme...
- A predictive coding account of MMN reduction in sc...
- Successful cutting balloon angioplasty in a child ...
- Development of repeatable arrays of proteins using...
- Materials, Vol. 8, Pages 7650-7662: High Temperatu...
- Microorganisms, Vol. 3, Pages 866-889: Hydrogen Su...
- Microorganisms, Vol. 3, Pages 851-865: Bioactiviti...
- Molecules, Vol. 20, Pages 20297-20311: Derinat Pro...
- Materials, Vol. 8, Pages 7663-7672: Enhanced Erbiu...
- Prenatal diagnosis of single gene disorders using ...
- Identification of biomarkers to measure HIV-specif...
- Dynamics and role of antibodies to Plasmodium falc...
- Metals, Vol. 5, Pages 2119-2127: Liquid Phase Sepa...
- Metals, Vol. 5, Pages 2109-2118: Dynamic Strain Ev...
- Life, Vol. 5, Pages 1610-1628: Non-Standard Geneti...
- Life, Vol. 5, Pages 1587-1609: Starvation-Survival...
- Laws, Vol. 4, Pages 709-728: The Convention for th...
- Molecules, Vol. 20, Pages 20286-20296: β–Cyclodext...
- Effect of anti-oxidant agents in patients with hep...
- Healthcare, Vol. 3, Pages 1158-1173: The Applicati...
- Games, Vol. 6, Pages 604-636: The Role of Implicit...
- Entropy, Vol. 17, Pages 7680-7697: Using Expectati...
- Forests, Vol. 6, Pages 4088-4104: Characterization...
- Coatings, Vol. 5, Pages 830-864: The Search for Du...
- Coatings, Vol. 5, Pages 816-829: Natural Deposit C...
- Catalysts, Vol. 5, Pages 1928-1947: Molybdenum (VI...
- Catalysts, Vol. 5, Pages 1911-1927: Zr-SBA-15 Lewi...
- Catalysts, Vol. 5, Pages 1897-1910: Direct Convers...
- Biomolecules, Vol. 5, Pages 3142-3176: Immune Mech...
- Microarrays, Vol. 4, Pages 551-569: SNPs Array Kar...
- Applied Sciences, Vol. 5, Pages 1134-1163: An Effi...
- JDB, Vol. 3, Pages 93-111: Pbx4 is Required for th...
- Reproductive history and risk of cognitive impairm...
- Toxins, Vol. 7, Pages 4706-4729: Metabolism of Deo...
- Reasons & Symptoms of Dengue Fever
- Intra-individual lap time variation of the 400-m w...
- IJMS, Vol. 16, Pages 27032-27043: A PPO Promoter f...
- IJMS, Vol. 16, Pages 27015-27031: Sildenafil Prote...
-
▼
Νοε 12
(48)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 12 Νοεμβρίου 2015
Molecules, Vol. 20, Pages 20312-20319: Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.